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SIRP gamma (CD172g) recognizes a 55 kDa signal regulatory protein which is a member of the immunoglobulin gene superfamily. SIRP gamma is expressed on most T lymphocytes and a subset of B-cells but is absent on myeloid cells. CD172g has a truncated cytoplasmic tail, which is similar to SIRP beta, but unlike SIRP beta CD172g does not require DAP12 for expression at the cell surface. CD172g, like SIRP alpha, binds to CD47 inducing apoptosis. SIRP gamma is also involved in the negative regulation of receptor tyrosine kinase-coupled signalling.
bA77C3.1; CD172 antigen-like family member B; CD172 gamma; CD172g; CD172g antigen; RP11-77C3.2; signal regulatory protein gamma; signal-regulatory protein beta 2; signal-regulatory protein beta-2; Signal-regulatory protein gamma; SIRP beta 2; SIRPB2; SIRP-B2; SIRP-beta-2; SIRPG; SIRPgamma; SIRP-gamma
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